{"id":37,"date":"2025-02-07T14:10:25","date_gmt":"2025-02-07T05:10:25","guid":{"rendered":"https:\/\/hifumin.com\/?p=37"},"modified":"2025-02-07T14:11:44","modified_gmt":"2025-02-07T05:11:44","slug":"uv-antioxidant-protection","status":"publish","type":"post","link":"https:\/\/hifumin.com\/?p=37","title":{"rendered":"\u76ae\u819a\u79d1\u5c02\u9580\u533b\u304c\u89e3\u8aac\uff01\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\u3067\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u9632\u3050\u65b9\u6cd5"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u306f\u3058\u3081\u306b<\/h2>\n\n\n\n<p>\u7686\u3055\u3093\u3001\u3053\u3093\u306b\u3061\u306f\u3002\u7f8e\u808c\u3084\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u306b\u95a2\u5fc3\u306e\u3042\u308b\u65b9\u306b\u6717\u5831\u3067\u3059\uff01\u7d2b\u5916\u7dda\u306b\u3088\u308b\u808c\u30c0\u30e1\u30fc\u30b8\u306f\u3001\u30b7\u30df\u3084\u30b7\u30ef\u3001\u6700\u60aa\u306e\u5834\u5408\u76ae\u819a\u304c\u3093\u306e\u539f\u56e0\u306b\u3082\u306a\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\u306e\u529b\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306f\u30012005\u5e74\u306b\u767a\u8868\u3055\u308c\u305f\u8ad6\u6587\u300cUltraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol\u300d\u3092\u3082\u3068\u306b\u3001\u30d3\u30bf\u30df\u30f3C\u3068\u30d3\u30bf\u30df\u30f3E\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u304b\u3089\u808c\u3092\u5b88\u308b\u306e\u304b\u3092\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u3066\u308f\u304b\u308a\u3084\u3059\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u8ad6\u6587\u306e\u6982\u8981\u3068\u8a66\u9a13\u306e\u57fa\u672c\u60c5\u5831<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u7814\u7a76\u306e\u76ee\u7684\u3068\u80cc\u666f<\/h3>\n\n\n\n<p>\u7d2b\u5916\u7dda\uff08UV\uff09\u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u308bDNA\u306e\u640d\u50b7\u306f\u3001\u76ae\u819a\u304c\u3093\u767a\u751f\u306e\u4e3b\u8981\u306a\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u6297\u9178\u5316\u4f5c\u7528\u3092\u6301\u3064\u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u3068\u30d3\u30bf\u30df\u30f3E\uff08D-\u03b1-\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb\uff09\u306f\u3001\u4f53\u5185\u3067\u767a\u751f\u3059\u308b\u6709\u5bb3\u306a\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u3092\u9664\u53bb\u3057\u3001\u7d30\u80de\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u9632\u3050\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u9577\u671f\u306b\u308f\u305f\u308b\u7d4c\u53e3\u6442\u53d6\u304c\u5b9f\u969b\u306b\u808c\u306e\u7d2b\u5916\u7dda\u53cd\u5fdc\u3092\u6539\u5584\u3057\u3001DNA\u30c0\u30e1\u30fc\u30b8\u3092\u8efd\u6e1b\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u8a66\u9a13\u306e\u57fa\u672c\u60c5\u5831\uff08\u308f\u304b\u308a\u3084\u3059\u3044PICO\u306e\u8aac\u660e\uff09<\/h3>\n\n\n\n<p><strong>\u5bfe\u8c61\uff08Participants\uff09:<\/strong> 18\u540d\u306e\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\uff08\u7537\u602712\u540d\u3001\u5973\u60276\u540d\uff09\u3067\u3001\u4e3b\u306b\u808c\u30bf\u30a4\u30d7II\uff5eIII\u306e\u65b9\u3005\u304c\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002<br><strong>\u4ecb\u5165\uff08Intervention\uff09:<\/strong> \u6bce\u65e5\u3001\u30d3\u30bf\u30df\u30f3C 1g\u3068\u30d3\u30bf\u30df\u30f3E 500 IU\u30921\u65e52\u56de\u3001\u5408\u8a083\u304b\u6708\u9593\u670d\u7528\u3002<br><strong>\u6bd4\u8f03\uff08Comparison\uff09:<\/strong> \u6297\u9178\u5316\u7269\u8cea\u3092\u670d\u7528\u3059\u308b\u524d\u3068\u5f8c\u3067\u3001\u7d2b\u5916\u7dda\uff08UVB\uff09\u306b\u3088\u308b\u808c\u306e\u53cd\u5fdc\u3092\u6bd4\u8f03\u3002<br><strong>\u7d50\u679c\uff08Outcome\uff09:<\/strong> \u7d2b\u5916\u7dda\u306b\u3088\u308b\u8d64\u307f\uff08\u30b5\u30f3\u30d0\u30fc\u30f3\uff09\u306e\u767a\u751f\u3057\u3084\u3059\u3055\uff08\u6700\u5c0f\u7d05\u6591\u91cf\uff1dMED\uff09\u3068\u3001DNA\u306e\u640d\u50b7\u3092\u793a\u3059\u30b5\u30a4\u30f3\uff08\u30c1\u30df\u30f3\u30c0\u30a4\u30de\u30fc\uff09\u306e\u6570\u3092\u6e2c\u5b9a\u3002<\/p>\n\n\n\n<p>\u203b\u300c\u30c1\u30df\u30f3\u30c0\u30a4\u30de\u30fc\u300d\u3068\u306f\u3001DNA\u306e\u4e2d\u3067\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u96a3\u308a\u5408\u3046\u30c1\u30df\u30f3\u3068\u3044\u3046\u5869\u57fa\u304c\u304f\u3063\u3064\u3044\u3066\u3057\u307e\u3044\u3001\u6b63\u5e38\u306aDNA\u306e\u50cd\u304d\u3092\u963b\u5bb3\u3059\u308b\u640d\u50b7\u306e\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b9f\u9a13\u7d50\u679c\u306e\u7d39\u4ecb<\/h2>\n\n\n\n<p>\u7814\u7a76\u306e\u7d50\u679c\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8840\u4e2d\u30d3\u30bf\u30df\u30f3\u6fc3\u5ea6\u306e\u4e0a\u6607\uff1a<\/strong> 1\u304b\u6708\u4ee5\u5185\u306b\u30d3\u30bf\u30df\u30f3C\u3068\u30d3\u30bf\u30df\u30f3E\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u5927\u5e45\u306b\u4e0a\u6607\u3057\u30013\u304b\u6708\u3067\u306f\u5b89\u5b9a\u3057\u305f\u9ad8\u3044\u30ec\u30d9\u30eb\u3092\u7dad\u6301\u3002<\/li>\n\n\n\n<li><strong>\u30b5\u30f3\u30d0\u30fc\u30f3\u53cd\u5fdc\u306e\u8efd\u6e1b\uff1a<\/strong> \u6297\u9178\u5316\u7269\u8cea\u670d\u7528\u524d\u306eMED\u304c80 mJ\/cm<sup>2<\/sup>\u306b\u5bfe\u3057\u30013\u304b\u6708\u5f8c\u306b\u306f113 mJ\/cm<sup>2<\/sup>\u306b\u4e0a\u6607\u3002\u3064\u307e\u308a\u3001\u540c\u3058\u91cf\u306e\u7d2b\u5916\u7dda\u306b\u5bfe\u3057\u3066\u808c\u304c\u8d64\u304f\u306a\u308a\u306b\u304f\u304f\u306a\u3063\u305f\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>DNA\u640d\u50b7\u306e\u6e1b\u5c11\uff1a<\/strong> UVB\u7167\u5c04\u5f8c\u306b\u767a\u751f\u3059\u308b\u30c1\u30df\u30f3\u30c0\u30a4\u30de\u30fc\u306e\u6570\u304c\u3001\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\u670d\u7528\u5f8c\u306b\u306f\u6709\u610f\u306b\u6e1b\u5c11\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u306e\u76f4\u63a5\u7684\u306a\u30c0\u30e1\u30fc\u30b8\u304c\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u7d4c\u53e3\u6442\u53d6\u306b\u3088\u308b\u30d3\u30bf\u30df\u30f3C\u3068\u30d3\u30bf\u30df\u30f3E\u306e\u4f75\u7528\u306f\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u808c\u30c0\u30e1\u30fc\u30b8\u306b\u5bfe\u3057\u3066\u6709\u52b9\u306a\u4e88\u9632\u7b56\u3068\u306a\u308a\u5f97\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u80af\u5b9a\u7684\u306a\u8003\u5bdf<\/h2>\n\n\n\n<p>\u3053\u306e\u7814\u7a76\u306f\u3001\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\u306e\u7d4c\u53e3\u6442\u53d6\u304c\u3001\u5358\u306b\u30b5\u30f3\u30d0\u30fc\u30f3\u3092\u8efd\u6e1b\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001DNA\u30ec\u30d9\u30eb\u3067\u306e\u640d\u50b7\u3082\u6291\u3048\u308b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u7f8e\u5bb9\u9762\u3067\u8a00\u3048\u3070\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u8001\u5316\u73fe\u8c61\u3084\u30b7\u30df\u30fb\u30b7\u30ef\u306e\u767a\u751f\u3092\u4e88\u9632\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u65e5\u3005\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u5065\u5eb7\u7dad\u6301\u306b\u53d6\u308a\u5165\u308c\u308b\u30e1\u30ea\u30c3\u30c8\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u5185\u5074\u304b\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3044\u3046\u70b9\u3067\u3001\u5916\u7528\u306e\u30af\u30ea\u30fc\u30e0\u306a\u3069\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u7dcf\u5408\u7684\u306a\u7d2b\u5916\u7dda\u5bfe\u7b56\u304c\u53ef\u80fd\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6279\u5224\u7684\u306a\u8003\u5bdf<\/h2>\n\n\n\n<p>\u4e00\u65b9\u3067\u3001\u3053\u306e\u7814\u7a76\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u7559\u610f\u70b9\u3082\u3042\u308a\u307e\u3059\u3002\u307e\u305a\u3001\u53c2\u52a0\u8005\u6570\u304c18\u540d\u3068\u5c11\u6570\u3067\u3042\u308a\u3001\u7d50\u679c\u306e\u4e00\u822c\u5316\u306b\u306f\u614e\u91cd\u3055\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u88ab\u9a13\u8005\u306f\u77ed\u671f\u9593\u306e\u8a55\u4fa1\u3067\u3042\u308a\u3001\u5b9f\u969b\u306b\u76ae\u819a\u304c\u3093\u306a\u3069\u306e\u9577\u671f\u7684\u306a\u5065\u5eb7\u30ea\u30b9\u30af\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u3001\u3055\u3089\u306a\u308b\u9577\u671f\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u7d4c\u53e3\u6442\u53d6\u306b\u3088\u308b\u6297\u9178\u5316\u7269\u8cea\u306e\u52b9\u679c\u306f\u500b\u4eba\u5dee\u304c\u5927\u304d\u304f\u3001\u65e5\u5e38\u751f\u6d3b\u3067\u306e\u7d2b\u5916\u7dda\u66b4\u9732\u3084\u751f\u6d3b\u7fd2\u6163\u3068\u3082\u5bc6\u63a5\u306b\u95a2\u9023\u3059\u308b\u305f\u3081\u3001\u5358\u72ec\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6442\u53d6\u3060\u3051\u3067\u5b8c\u5168\u306a\u4fdd\u8b77\u304c\u5f97\u3089\u308c\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u307e\u3068\u3081<\/h2>\n\n\n\n<p>\u4eca\u56de\u3054\u7d39\u4ecb\u3057\u305f\u8ad6\u6587\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u3068\u30d3\u30bf\u30df\u30f3E\u306e\u7d4c\u53e3\u6442\u53d6\u304c\u7d2b\u5916\u7dda\u306b\u3088\u308b\u30b5\u30f3\u30d0\u30fc\u30f3\u53cd\u5fdc\u3084DNA\u640d\u50b7\u3092\u6709\u610f\u306b\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u6297\u9178\u5316\u30d3\u30bf\u30df\u30f3\u304c\u5185\u5074\u304b\u3089\u306e\u7d2b\u5916\u7dda\u5bfe\u7b56\u3068\u3057\u3066\u6709\u671b\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u30b5\u30f3\u30d7\u30eb\u6570\u3084\u8a55\u4fa1\u671f\u9593\u306a\u3069\u306e\u5236\u9650\u3082\u3042\u308b\u305f\u3081\u3001\u65e5\u5e38\u7684\u306a\u30b9\u30ad\u30f3\u30b1\u30a2\u3068\u3057\u3066\u53d6\u308a\u5165\u308c\u308b\u969b\u306b\u306f\u3001\u30d0\u30e9\u30f3\u30b9\u306e\u826f\u3044\u751f\u6d3b\u7fd2\u6163\u3084\u9069\u5207\u306a\u7d2b\u5916\u7dda\u5bfe\u7b56\uff08\u65e5\u713c\u3051\u6b62\u3081\u3001\u5e3d\u5b50\u3001\u65e5\u5098\u306a\u3069\uff09\u3068\u306e\u4f75\u7528\u304c\u91cd\u8981\u3067\u3059\u3002\u4eca\u5f8c\u306e\u3055\u3089\u306a\u308b\u7814\u7a76\u306b\u3088\u308a\u3001\u3088\u308a\u78ba\u56fa\u305f\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u84c4\u7a4d\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<p>Placzek, Marianne, et al. \u201cUltraviolet B-induced DNA damage in human epidermis is modified by the antioxidants ascorbic acid and D-alpha-tocopherol.\u201d <em>The Journal of Investigative Dermatology<\/em>, vol. 124, no. 2, 2005, pp. 304-307. doi:10.1111\/j.0022-202X.2004.23560.x.<\/p>\n\n\n\n<hr class=\"wp-block-separator 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